Apoptotic cells fail to stimulate phagocyte to stimulate phagocyte proinflammatory mediator release
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Apoptotic cells induce the release of anti-inflammatory mediators
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Macrophage receptors mediating apoptotic cell recognition
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Integrins
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Class A and Class B scavenger receptors; other oxLDL receptors
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CD14
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Aminophospholipid translocase
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Devaux, P.F., et al. 1990. Control of the transmembrane phospholipid distribution in eukaryotic cells by aminophospholipid translocase. Biotechnol. Appl. Biochem. 12:517-522.
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Phospholipid scramblase
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Annexin V as a marker for apoptosis
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PKC delta cleaveage during apoptosis by caspase 3
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Oxidation of phosphatidylserine during apoptosis
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Oxidized phospholipids likely provide a ligand for recognition by scavenger receptors
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Scavenger receptors and other oxLDLR bind phosphatidylserine
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Surface blebs on apoptotic cells contain autoantigens
Casciola-Rosen, L.A., Anhalt, G., and Rosen, A. 1994. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179:1317-1330.
Casciola-Rosen, L., and Rosen, A. 1997. Ultraviolet light-induced keratinocyte apoptosis: a potential mechanism for the induction of skin lesions and autoantibody production in LE. Lupus. 6:175-180.
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PtdSer may activate complement directly
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ICAM-3 on apoptotic cells as recognition marker
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Production of IL10 by phagocytes in response to apoptotic cells
Niederkorn, J.Y. 1999. Anterior chamber-associated immune deviation. Chem. Immunol. 73:59-71.
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Dendritic cell response to apoptotic cells
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Anti-inflammatory effects of phosphatidylserine
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