Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling -- Küppers et al. 111 (4): 529 Data Supplement - Supplemental data -- Journal of Clinical Investigation

Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
J. Clin. Invest. Küppers et al. 111 (4): 529.

Supplemental data

Figure 1

Figure 2

Supplementary Figure 1

The gene expression profile of HL lines is related to that of LCL and ABC-type DLCL. Dendrogram and matrix showing the hierarchical clustering of gene expression data (see Methods for criteria) generated from 23 transformed B cell lines derived from HL, DLCL, BL, and EBV-transformed peripheral blood B cells (LCL). The hierarchical clustering algorithm used to generate the dendrogram is based on the average-linkage method (17). Cell lines are color-coded according to their cellular origin: DLCL, red; BL, blue; HL, green; LCL, violet. If known, the EBV status is indicated in brackets. ABC- or GC-type DLCL subtypes are indicated. The matrix below the dendrogram depicts the gene expression values of the individual samples, with columns representing individual tumor samples and rows representing individual genes ordered according to hierarchical clustering. The color scale identifies relative gene expression changes normalized by the SD, with 0 representing the mean expression level of a given gene across the panel.

Supplementary Figure 2

Protein expression of Hodgkin-specific genes in HL cell lines (L1236, L428, KMH2, HDLM2) in comparison with two BL cell lines (BL41 and BL2) and Jurkat as a T cell lymphoma cell line. The protein bands were of expected length. Actin is shown as a loading control.

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